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PDE1 inhibitor 4b

Chemical Structure : PDE1 inhibitor 4b

CAS No.:

PDE1 inhibitor 4b

Catalog No.: PC-25390Not For Human Use, Lab Use Only.

PDE1 inhibitor 4b is a potent, highly selective PDE1 inhibitor with IC50 of 5 nM, >147-fold selective over other PDEs, exhibits good antipulmonary fibrosis effects both in vitro and in vivo by suppressing the TGF-β/Smad and MAPK signaling pathway.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PDE1 inhibitor 4b is a potent, highly selective PDE1 inhibitor with IC50 of 5 nM, >147-fold selective over other PDEs, exhibits good antipulmonary fibrosis effects both in vitro and in vivo by suppressing the TGF-β/Smad and MAPK signaling pathway.

Physicochemical Properties

M.Wt 423.42
Formula C24H19F2NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(Z)-1-(5-Fluoro-2-isopropoxybenzylidene)-6-(4-fluorobenzyl)furo[3,4-c] pyridine-3,4(1H,5H)-dione

References

1. Jiang MY, et al. J Med Chem. 2025 Aug 22. doi: 10.1021/acs.jmedchem.5c01238.

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