Chemical Structure : PDE1 inhibitor 4b
Catalog No.: PC-25390Not For Human Use, Lab Use Only.
PDE1 inhibitor 4b is a potent, highly selective PDE1 inhibitor with IC50 of 5 nM, >147-fold selective over other PDEs, exhibits good antipulmonary fibrosis effects both in vitro and in vivo by suppressing the TGF-β/Smad and MAPK signaling pathway.
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PDE1 inhibitor 4b is a potent, highly selective PDE1 inhibitor with IC50 of 5 nM, >147-fold selective over other PDEs, exhibits good antipulmonary fibrosis effects both in vitro and in vivo by suppressing the TGF-β/Smad and MAPK signaling pathway.
M.Wt | 423.42 | |
Formula | C24H19F2NO4 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Jiang MY, et al. J Med Chem. 2025 Aug 22. doi: 10.1021/acs.jmedchem.5c01238.
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