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PDE2 inhibitor 4

Chemical Structure : PDE2 inhibitor 4

CAS No.: 2055160-19-3

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PDE2 inhibitor 4

Catalog No.: PC-35839Not For Human Use, Lab Use Only.

PDE2 inhibitor 4 is a potent, selective, orally available inhibitor of PDE2 with IC50 of 2 nM, displays high selectivity versus other PDE isoforms.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PDE2 inhibitor 4 is a potent, selective, orally available inhibitor of PDE2 with IC50 of 2 nM, displays high selectivity versus other PDE isoforms.
    PDE2 inhibitor 4 exhibits excellent pharmacokinetic properties in multiple species and improves cognitive performance in both the rat Novel Object Recognition and rhesus Object Recognition assays.

    Physicochemical Properties

    M.Wt 352.317
    Formula C16H15F3N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-3-(hydroxymethyl)-6-methyl-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

    References

    1. Stachel SJ, et al. ACS Med Chem Lett. 2018 Jul 26;9(8):815-820.

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