Chemical Structure : PDE3B inhibitor 8a
CAS No.:
644984-68-9
PDE3B inhibitor 8a
(PDE3B-IN-2)
Catalog No.: PC-25898Not For Human Use, Lab Use Only.
PDE3B inhibitor 8a (PDE3B-IN-2) is a potent, subtype selective, orally active PDE3B inhibitor with IC50 of 0.19 nM and 1.3 nM for PDE3B and PDE3A respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PDE3B inhibitor 8a (PDE3B-IN-2) is a potent, subtype selective, orally active PDE3B inhibitor with IC50 of 0.19 nM and 1.3 nM for PDE3B and PDE3A respectively.
PDE3B inhibitor 8a is 7-fold selective for PDE3B over 3A.
PDE3B inhibitor 8a caused a dose dependent increase in glycerol levels, with an ED50=0.60 mg/kg in anesthetized rats.
PDE3B inhibitor 8a stimulated lipolysis in adipocytes with an ED50=0.6 mg/kg.
PDE3B inhibitor 8a showed a significant lowering of blood pressure in the rat at doses as low as 0.01 mg/kg.
Physicochemical Properties
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M.Wt
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387.48
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Formula
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C24H25N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-6-(4-((2-benzyl-3-oxocyclohex-1-en-1-yl)amino)phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
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References
1. Edmondson SD, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3983-7.
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