Chemical Structure : PDE3 inhibitor K-134
CAS No.:
189362-06-9
PDE3 inhibitor K-134
(OPC-33509, OPC33509, K134)
Catalog No.: PC-28250Not For Human Use, Lab Use Only.
K-134 (OPC-33509) is a potent, selective phosphodiesterase-3 (PDE3) inhibitor with IC50 of 0.1 uM and 0.28 uM for PDE3A and PDE3B, shows much weaker activity for PDE5 and does not inhibit PDE2 and PDE4.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
K-134 (OPC-33509) is a potent, selective phosphodiesterase-3 (PDE3) inhibitor with IC50 of 0.1 uM and 0.28 uM for PDE3A and PDE3B, shows much weaker activity for PDE5 and does not inhibit PDE2 and PDE4.
K-134 also inhibits binding between CD36 and collagen type-I.
K-134 blocks rat platelet aggregation more potently than cilostazol in vitro.
K-134 inhibits mouse platelet aggregation induced by collagen and ADP in a dose-dependent manner.
Physicochemical Properties
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M.Wt
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399.49
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Formula
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C22H29N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-cyclopropyl-1-((1R,2R)-2-hydroxycyclohexyl)-3-(3-((2-oxo-1,2-dihydroquinolin-6-yl)oxy)propyl)urea
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References
1. Yoshida H, et al. PLoS One. 2012;7(10):e46432.
2. Sasaki Y, et al. Eur J Pharmacol. 2012 Aug 15;689(1-3):132-8.
3. Ikenoya M, et al. Biochem Biophys Res Commun. 2007 Feb 23;353(4):1111-4.
4. Sudo T, et al. Biochem Pharmacol 2000, 59: 347–356.
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