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PDE4D-IN-26b

Chemical Structure : PDE4D-IN-26b

CAS No.: 1252807-76-3

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PDE4D-IN-26b (PDE4D inhibitor 26b)

Catalog No.: PC-63121Not For Human Use, Lab Use Only.

PDE4D-IN-26b is a potent, highly selective PDE4D inhibitor with IC50 of 0.6 nM, displays 75-fold lower activity against the PDE4A, B, and C subtypes, also exhibits 18,000-fold decreased potency against other PDE family members.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PDE4D-IN-26b is a potent, highly selective PDE4D inhibitor with IC50 of 0.6 nM, displays 75-fold lower activity against the PDE4A, B, and C subtypes, also exhibits 18,000-fold decreased potency against other PDE family members.
    PDE4D-IN-26b suppresses PDE4D-dependent malignant cell growth, but not in nonmalignant epithelial cells.

    Physicochemical Properties

    M.Wt 463.525
    Formula C28H27F2NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-((8-(3-(difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-ol

    References

    1. Lin DC, et al. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6109-14.

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