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PDE4D-IN-26b

Chemical Structure : PDE4D-IN-26b

CAS No.: 1252807-76-3

PDE4D-IN-26b

Catalog No.: PC-63121Not For Human Use, Lab Use Only.

PDE4D-IN-26b is a potent, highly selective PDE4D inhibitor with IC50 of 0.6 nM, displays 75-fold lower activity against the PDE4A, B, and C subtypes, also exhibits 18,000-fold decreased potency against other PDE family members.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PDE4D-IN-26b is a potent, highly selective PDE4D inhibitor with IC50 of 0.6 nM, displays 75-fold lower activity against the PDE4A, B, and C subtypes, also exhibits 18,000-fold decreased potency against other PDE family members; suppresses PDE4D-dependent malignant cell growth, but not in nonmalignant epithelial cells.

Physicochemical Properties

M.Wt 463.525
Formula C28H27F2NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(4-((8-(3-(difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-ol

References

1. Lin DC, et al. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6109-14.

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