PDE4 activator MR-L2 (MR-L2) is a small-molecule PDE4 activator, phenocopies PKA-mediated activation of long PDE4 isoforms.
MR-L2 reduces intracellular cAMP in MDCK cells without affecting PDE4 expression or cell viability.
MR-L2 suppresses the maximal cyst response elicited by both direct and indirect activation of adenylyl cyclase.
MR-L2 inhibits cyst formation in human models of ADPKD, also clearly suppresses the number of cysts formed in 3D culture in both unstimulated and vasopressin-treated (10 nM) cell cultures
