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Chemical Structure : PDE4 activator MR-L2
CAS No.: 2374703-19-0
Catalog No.: PC-73022Not For Human Use, Lab Use Only.
PDE4 activator MR-L2 (MR-L2) is a small-molecule PDE4 activator, phenocopies PKA-mediated activation of long PDE4 isoforms.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $428 | In stock | |
| 50 mg | $988 | In stock | |
| 100 mg | Get quote |
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PDE4 activator MR-L2 (MR-L2) is a small-molecule PDE4 activator, phenocopies PKA-mediated activation of long PDE4 isoforms.
MR-L2 reduces intracellular cAMP in MDCK cells without affecting PDE4 expression or cell viability.
MR-L2 suppresses the maximal cyst response elicited by both direct and indirect activation of adenylyl cyclase.
MR-L2 inhibits cyst formation in human models of ADPKD, also clearly suppresses the number of cysts formed in 3D culture in both unstimulated and vasopressin-treated (10 nM) cell cultures
| M.Wt | 441.712 | |
| Formula | C19H16Cl3FN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(3-(4-chloro-3-fluorophenyl)-5-ethyl-1H-1,2,4-triazol-1-yl)-N-(3,5-dichlorobenzyl)acetamide |
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1. Omar F, et al. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329.
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