PDE5-IN-6c | PDE5 inhibitor | Probechem Biochemicals

Chemical Structure : PDE5-IN-6c

PDE5-IN-6c (PDE5 inhibitor 6c)

Catalog No.: PC-60093Not For Human Use, Lab Use Only.

PDE5-IN-6c is a potent, selective PDE5 inhibitor with IC50 of 0.056 nM for PDE5A1.

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Biological Activity

PDE5-IN-6c is a potent, selective PDE5 inhibitor with IC50 of 0.056 nM for PDE5A1.
PDE5-IN-6c displays >500-fold selectivity over PDE6.
PDE5-IN-6c exhibits good efficacy in mouse model of Alzheimer's disease.

Physicochemical Properties

M.Wt	420.897
Formula	C23H21ClN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Acetyl-10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

References

1. Fiorito J, et al. J Med Chem. 2017 Nov 9;60(21):8858-8875.

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PDE5-IN-6c (PDE5 inhibitor 6c)

Biological Activity

Physicochemical Properties

References

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