PDE8 inhibitor 15

Chemical Structure : PDE8 inhibitor 15

Catalog No.: PC-23488Not For Human Use, Lab Use Only.

PDE8 inhibitor 15 is a potent, selective phosphodiesterase 8A (PDE8A) inhibitor with IC50 of 11 nM (PDE8A), high selectivity over other PDEs.

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Biological Activity

PDE8 inhibitor 15 is a potent, selective phosphodiesterase 8A (PDE8A) inhibitor with IC50 of 11 nM (PDE8A), high selectivity over other PDEs.
PDE8 inhibitor 15 (2.5 mg/kg and 5.0 mg/kg, p.o.) significantly improved the cAMP level of the right brain and exhibited dose-dependent effects on cognitive improvement in a vascular dementia (VaD) mouse model.

Physicochemical Properties

M.Wt	405.74
Formula	C15H12ClF4N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-9-(3-(2,2-difluoroethoxy)-5-(difluoromethoxy)benzyl)-9H-purin-6-amine

References

1. Wu XN, et al. Acta Pharm Sin B. 2022 Jul;12(7):3103-3112.

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