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PDM-631

Chemical Structure : PDM-631

CAS No.: 2095312-08-4

PDM-631 (PDM 631, PDM631)

Catalog No.: PC-60365Not For Human Use, Lab Use Only.

PDM-631 is a potent, selective, brain-penetrable and orally active PDE2A inhibitor with IC50 of 1.5 and 4.2 nM for human and rat PDE2A, respectively.

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    Biological Activity

    PDM-631 is a potent, selective, brain-penetrable and orally active PDE2A inhibitor with IC50 of 1.5 and 4.2 nM for human and rat PDE2A, respectively.
    PDM-631 displays >2,000-fold selectivity against other PDEs.
    PDM-631 increases object recognition memory, does not show an antipsychotic-like effect in mice.
    PDM-631 is a good pharmacological tool that can be used to investigate the role of PDE2A and may have therapeutic potential for the treatment of cognitive impairments associated with schizophrenia and neurodegenerative disorders, without any extrapyramidal side effects.

    Physicochemical Properties

    M.Wt 392.38
    Formula C19H19F3N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-3-cyclopropyl-6-methyl-1-(1-(4-(trifluoromethoxy)phenyl)propan-2-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

    References

    1. Maehara S, et al. Eur J Pharmacol. 2017 Sep 15;811:110-116.

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