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PDM-631

Chemical Structure : PDM-631

CAS No.: 2095312-08-4

PDM-631 (PDM 631;PDM631)

Catalog No.: PC-60365Not For Human Use, Lab Use Only.

A novel potent, selective, brain-penetrable and orally active PDE2A inhibitor with IC50 of 1.5 and 4.2 nM for human and rat PDE2A, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel potent, selective, brain-penetrable and orally active PDE2A inhibitor with IC50 of 1.5 and 4.2 nM for human and rat PDE2A, respectively; displays >2,000-fold selectivity against other PDEs; increases object recognition memory, does not show an antipsychotic-like effect in mice; a good pharmacological tool that can be used to investigate the role of PDE2A and may have therapeutic potential for the treatment of cognitive impairments associated with schizophrenia and neurodegenerative disorders, without any extrapyramidal side effects.

Physicochemical Properties

M.Wt 392.38
Formula C19H19F3N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-3-cyclopropyl-6-methyl-1-(1-(4-(trifluoromethoxy)phenyl)propan-2-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

References

1. Maehara S, et al. Eur J Pharmacol. 2017 Sep 15;811:110-116.

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