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Chemical Structure : PEPA
CAS No.: 141286-78-4
Catalog No.: PC-43078Not For Human Use, Lab Use Only.
PEPA is an allosteric potentiator of AMPA receptors, potentiates glutamate responses by 50-fold in oocytes expressing GluRCflop (EC50=50 uM).
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|---|---|---|---|
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| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
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PEPA is an allosteric potentiator of AMPA receptors, potentiates glutamate responses by 50-fold in oocytes expressing GluRCflop (EC50=50 uM).
PEPA dose dependently potentiates glutamate-evoked currents in Xenopus oocytes expressing AMPA (GluRA-GluRD), but not kainate (GluR6 and GluR6+KA2) or NMDA (zeta1 + epsilon1-epsilon4), receptor subunits at 1-200 uM.
PEPA markedly slows the rate of onset of desensitization and potentiates steady-state equilibrium currents evoked by glutamate with subunit (GluRC >/= GluRD > GluRA) and splice-variant (flop > flip) selectivity.
| M.Wt | 402.436 | |
| Formula | C16H16F2N2O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Acetamide, 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]- |
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1. Sekiguchi M, et al. J Neurosci. 1997 Aug 1;17(15):5760-71.
2. Sekiguchi M, et al. Br J Pharmacol. 1998 Apr;123(7):1294-303.
3. Shen Y, et al. Neuroscience. 1999 Mar;89(3):979-90.
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