PF-02575799 |CAS:863491-70-7 Probechem Biochemicals

Chemical Structure : PF-02575799

PF-02575799 (PF02575799)

Catalog No.: PC-63288Not For Human Use, Lab Use Only.

PF-02575799 is a highly potent microsomal triglyceride transfer protein (MTP) inhibitor with IC50 of 0.77 nM.

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Biological Activity

PF-02575799 is a highly potent microsomal triglyceride transfer protein (MTP) inhibitor with IC50 of 0.77 nM; produces appreciable triglyceride effects at its minimally effective dose (10 mg/kg), significantly increases alanine transaminase at 100 mg/kg.

Physicochemical Properties

M.Wt	680.78
Formula	C42H37FN4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1S)-2-[[(4-Fluorophenyl)methyl]methylamino]-2-oxo-1-phenylethyl]-2-[[[4'-(1-methylethoxy)[1,1'-biphenyl]-2-yl]carbonyl]amino]-6-quinolinecarboxamide

References

1. Robinson RP, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4150-4.

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PF-02575799 (PF02575799)

Biological Activity

Physicochemical Properties

References

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