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PF-02575799

Chemical Structure : PF-02575799

CAS No.: 863491-70-7

PF-02575799 (PF02575799)

Catalog No.: PC-63288Not For Human Use, Lab Use Only.

PF-02575799 is a highly potent microsomal triglyceride transfer protein (MTP) inhibitor with IC50 of 0.77 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PF-02575799 is a highly potent microsomal triglyceride transfer protein (MTP) inhibitor with IC50 of 0.77 nM; produces appreciable triglyceride effects at its minimally effective dose (10 mg/kg), significantly increases alanine transaminase at 100 mg/kg.

Physicochemical Properties

M.Wt 680.78
Formula C42H37FN4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[(1S)-2-[[(4-Fluorophenyl)methyl]methylamino]-2-oxo-1-phenylethyl]-2-[[[4'-(1-methylethoxy)[1,1'-biphenyl]-2-yl]carbonyl]amino]-6-quinolinecarboxamide

References

1. Robinson RP, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4150-4.

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