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PF-03049423

Chemical Structure : PF-03049423

CAS No.: 402955-58-2

PF-03049423 (PF 03049423)

Catalog No.: PC-61858Not For Human Use, Lab Use Only.

PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM; displays 158-fold and 2460-fold selectivity over PDE6 and PDE11, respectively; possesses an excellent potency and selectivity profile and demonstrates robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model.

Stroke

Phase 2 Discontinued

Physicochemical Properties

M.Wt 468.55
Formula C24H32N6O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[4-(2-Hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)-pyrido[3,4-b]pyrazin-2(1H)-one

References

1. Hughes RO, et al. J Med Chem. 2010 Mar 25;53(6):2656-60.

2. Di Cesare F, et al. J Stroke Cerebrovasc Dis. 2016 Mar;25(3):642-9.

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