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PF-03246799

Chemical Structure : PF-03246799

CAS No.: 1065110-62-4

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PF-03246799 (PF 03246799;PF03246799;PF-3246799;PF3246799)

Catalog No.: PC-61081Not For Human Use, Lab Use Only.

PF-03246799 (PF-3246799) is a potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-03246799 (PF-3246799) is a potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A.
    PF-03246799 (PF-3246799) has minimal activation at either the 5-HT(2A) or 5-HT(2B) receptors.
    PF-03246799 (PF-3246799)demonstrates robust efficacy in preclinical canine model of stress urinary incontinence (SUI) and attractive pharmacokinetic and safety properties.

    Physicochemical Properties

    M.Wt 239.322
    Formula C15H17N3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine

    References

    1. Andrews MD, et al. Bioorg Med Chem Lett. 2011 May 1;21(9):2715-20.

    2. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8.

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