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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Glycine Transporter (GlyT)-PF-0346275
PF-0346275

Chemical Structure : PF-0346275

CAS No.: 1173239-39-8

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PF-0346275 (PF 0346275)

Catalog No.: PC-61458Not For Human Use, Lab Use Only.

PF-0346275 is a potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-0346275 is a potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM).
    PF-0346275 demonstrates potent activity in elevating CSF levels of glycine in vivo (ED200, 3.5 mg/kg).

    Physicochemical Properties

    M.Wt 376.86
    Formula C19H22ClFN4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-chloro-4-fluorobenzyl)-1-methyl-N-(((1R,5S,6r)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl)methyl)-1H-imidazole-4-carboxamide

    References

    1. Lowe JA 3rd, et al. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2974-6.

    2. Yamamoto S, et al. Chem Pharm Bull (Tokyo). 2016;64(11):1630-1640.

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