Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PF-0346275
Catalog No.: PC-61458Not For Human Use, Lab Use Only.
PF-0346275 is a potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PF-0346275 is a potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM).
PF-0346275 demonstrates potent activity in elevating CSF levels of glycine in vivo (ED200, 3.5 mg/kg).
| M.Wt | 376.86 | |
| Formula | C19H22ClFN4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Lowe JA 3rd, et al. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2974-6.
2. Yamamoto S, et al. Chem Pharm Bull (Tokyo). 2016;64(11):1630-1640.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
