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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Glycine Transporter (GlyT)-PF-03463275
PF-03463275

Chemical Structure : PF-03463275

CAS No.: 1173239-39-8

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PF-03463275 (PF 3463275, PF 03463275)

Catalog No.: PC-61835Not For Human Use, Lab Use Only.

PF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM.
PF-03463275 shows no significant affinity for GlyT2 (Ki >1 mM).
PF-03463275 is under investigation for the treatment of schizophrenia.

Physicochemical Properties

M.Wt 376.86
Formula C19H22ClFN4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl]methyl]imidazole-4-carboxamide

References

1. Roberts BM, et al. Neuroreport. 2010 Mar 31;21(5):390-4.

2. Liu CN, et al. Cutan Ocul Toxicol. 2014 Sep;33(3):206-11.

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