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Chemical Structure : PF-03654746
Catalog No.: PC-63034Not For Human Use, Lab Use Only.
PF-03654746 (PF-3654746) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 2.3 nM.
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PF-03654746 (PF-3654746) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 2.3 nM.
PF-03654746 dislaplays >1000-fold selectivity versus H1, H2, H4 and other GPCRs (IC50>10 uM).
PF-03654746 possesses optimal pharmacological and pharmacokinetic profiles, shows potential in allergen-induced nasal symptoms.
| M.Wt | 322.4 | |
| Formula | C18H24F2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wager TT, et al. J Med Chem. 2011 Nov 10;54(21):7602-20.
2. Stokes JR, et al. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2.
3. Gallezot JD, et al. J Cereb Blood Flow Metab. 2017 Mar;37(3):1095-1107.
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