Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-GPCR-Histamine Receptor-PF-03654746
PF-03654746

Chemical Structure : PF-03654746

CAS No.: 935840-31-6

Add to Favorites

PF-03654746 (PF-3654746, PF03654746)

Catalog No.: PC-63034Not For Human Use, Lab Use Only.

PF-03654746 (PF-3654746) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 2.3 nM.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-03654746 (PF-3654746) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 2.3 nM.
    PF-03654746 dislaplays >1000-fold selectivity versus H1, H2, H4 and other GPCRs (IC50>10 uM).
    PF-03654746 possesses optimal pharmacological and pharmacokinetic profiles, shows potential in allergen-induced nasal symptoms.

    Physicochemical Properties

    M.Wt 322.4
    Formula C18H24F2N2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide

    References

    1. Wager TT, et al. J Med Chem. 2011 Nov 10;54(21):7602-20.

    2. Stokes JR, et al. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2.

    3. Gallezot JD, et al. J Cereb Blood Flow Metab. 2017 Mar;37(3):1095-1107.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: