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PF-03654764

Chemical Structure : PF-03654764

CAS No.: 935840-35-0

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PF-03654764 (PF-3654764)

Catalog No.: PC-63033Not For Human Use, Lab Use Only.

PF-03654764 (PF-3654764) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 1.4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-03654764 (PF-3654764) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 1.4 nM.
    PF-03654764 displays >1000-fold selectivity versus H1, H2, H4 and other GPCRs (IC50>10 uM).
    PF-03654764 possesses optimal pharmacological and pharmacokinetic profiles, shows potential in allergen-induced nasal symptoms.

    Physicochemical Properties

    M.Wt 322.454
    Formula C18H24F2N2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide

    References

    1. Wager TT, et al. J Med Chem. 2011 Nov 10;54(21):7602-20.

    2. North ML, et al. Allergy Asthma Clin Immunol. 2014 Jul 3;10(1):33.

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