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PF-03716556

Chemical Structure : PF-03716556

CAS No.: 928774-43-0

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PF-03716556 (PF03716556)

Catalog No.: PC-62889Not For Human Use, Lab Use Only.

PF-03716556 is a potent, selective, competitive and reversible gastric H+,K+-ATPase with pIC50 of 7.0 in porcine ion-tight membrane vesicle.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PF-03716556 is a potent, selective, competitive and reversible gastric H+,K+-ATPase with pIC50 of 7.0 in porcine ion-tight membrane vesicle; exhibits highly selective profile including the canine kidney Na+,K+-ATPase; inhibited gastric acid secretion in heidenhain pouch dogs (0.3-3mg/kg, p.o.), shows potentiation for the treatment of gastroesophageal reflux disease; orally biovailable.

Physicochemical Properties

M.Wt 394.5
Formula C22H26N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-imidazo[1,2-a]pyridine-6-carboxamide

References

1. Mori H, et al. J Pharmacol Exp Ther. 2009 Feb;328(2):671-9.

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