PF-03882845 (PF-3882845) is highly potent, selective, nonsteroidal, orally bioavailable Mineralocorticoid receptor (MR, MLR) antagonist with IC50 of 4.5 nM.
PF-03882845 displays >500-fold selectivity versus PR and other related nuclear hormone receptors.
PF-03882845 significantly increases urinary Na(+)/K(+) ratio in vivo.
PF-03882845 prevents renal injury with reduced risk of hyperkalemia in an animal model of nephropathy.
