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Chemical Structure : PF-03882845
Catalog No.: PC-61848Not For Human Use, Lab Use Only.
PF-03882845 (PF-3882845) is highly potent, selective, nonsteroidal, orally bioavailable Mineralocorticoid receptor (MR, MLR) antagonist with IC50 of 4.5 nM.
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PF-03882845 (PF-3882845) is highly potent, selective, nonsteroidal, orally bioavailable Mineralocorticoid receptor (MR, MLR) antagonist with IC50 of 4.5 nM.
PF-03882845 displays >500-fold selectivity versus PR and other related nuclear hormone receptors.
PF-03882845 significantly increases urinary Na(+)/K(+) ratio in vivo.
PF-03882845 prevents renal injury with reduced risk of hyperkalemia in an animal model of nephropathy.
| M.Wt | 419.91 | |
| Formula | C24H22ClN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Casimiro-Garcia A, et al. J Med Chem. 2014 May 22;57(10):4273-88.
2. Orena S, et al. Front Pharmacol. 2013 Oct 14;4:115.
3. Eudy RJ, et al. J Transl Med. 2011 Oct 21;9:180.
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