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PF-04191834

Chemical Structure : PF-04191834

CAS No.: 1029317-21-2

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PF-04191834 (PF-4191834)

Catalog No.: PC-61882Not For Human Use, Lab Use Only.

PF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM; displays 300‐fold over 12‐LO and 15‐LO, and no inhibition of the cyclooxygenase enzymes; is under clinical investigation for the oral treatment of asthma and pain.

Pain

Phase 2 Discontinued

Physicochemical Properties

M.Wt 393.502
Formula C22H23N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(3-((4-(1-methyl-1H-pyrazol-5-yl)phenyl)thio)phenyl)tetrahydro-2H-pyran-4-carboxamide

References

1. Masferrer JL, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):294-301.

2. Rzodkiewicz P, et al. Reumatologia. 2016;54(4):161-164. Epub 2016 Oct 5.

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