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PF-04418948

Chemical Structure : PF-04418948

CAS No.: 1078166-57-0

PF-04418948 (PF 04418948)

Catalog No.: PC-45579Not For Human Use, Lab Use Only.

PF-04418948 (PF 04418948) is a novel potent and selective prostaglandin EP2 receptor antagonist.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-04418948 (PF 04418948) is a novel potent and selective, orally active prostaglandin EP2 receptor antagonist.
PF-04418948 inhibits prostaglandin E(2)(PGE(2))-induced increase in cAMP in cells with a functional K(B) value of 1.8 nM.
PF-04418948 attenuates the butaprost-induced cutaneous blood flow response in rats.

Physicochemical Properties

M.Wt 409.407
Formula C23H20FNO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-Azetidinecarboxylic acid, 1-(4-fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-

References

1. af Forselles KJ, et al. Br J Pharmacol. 2011 Dec;164(7):1847-56.

2. Birrell MA, et al. Br J Pharmacol. 2013 Jan;168(1):129-38.

3. Kach J, et al. J Biol Chem. 2014 Mar 14;289(11):7505-13.

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