Chemical Structure : PF-04447943
CAS No.:
1082744-20-4
PF-04447943
(Edelinontrine, PF04447943, PF-4447943)
Catalog No. : PC-60205Not For Human Use, Lab Use Only.
PF-04447943 (Edelinontrine) is a potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6020501
Biological Activity
PF-04447943 (Edelinontrine) is a potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM.
Physicochemical Properties
M.Wt
395.47
Formula
C20H25N7O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
References
1. Hutson PH, et al. Neuropharmacology.
2. Verhoest PR, et al. J Med Chem.
3. Schwam EM, et al. Curr Alzheimer Res.
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