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Chemical Structure : PF-04447943
CAS No.: 1082744-20-4
Catalog No.: PC-60205Not For Human Use, Lab Use Only.
PF-04447943 (Edelinontrine) is a potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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PF-04447943 (Edelinontrine) is a potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM.
PF-04447943 displays high selectivity versus PDEs1-8 and 10-11 (>150-fold over PDE1C, IC50=1394 nM).
PF-04447943 significantly increases neurite outgrowth and synapse formation in cultured hippocampal neurons at 30-100 nM.
PF-04447943 enhances synaptic plasticity and cognitive function in rodents.
| M.Wt | 395.47 | |
| Formula | C20H25N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one |
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1. Hutson PH, et al. Neuropharmacology. 2011 Sep;61(4):665-76.
2. Verhoest PR, et al. J Med Chem. 2012 Nov 8;55(21):9045-54.
3. Schwam EM, et al. Curr Alzheimer Res. 2014;11(5):413-21.
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