PF-04447943 (Edelinontrine) | PDE9A inhibitor

Chemical Structure : PF-04447943

CAS No.: 1082744-20-4

PF-04447943 (Edelinontrine, PF04447943, PF-4447943)

Catalog No.: PC-60205Not For Human Use, Lab Use Only.

PF-04447943 (Edelinontrine) is a potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM.

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Biological Activity

PF-04447943 (Edelinontrine) is a potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM.
PF-04447943 displays high selectivity versus PDEs1-8 and 10-11 (>150-fold over PDE1C, IC50=1394 nM).
PF-04447943 significantly increases neurite outgrowth and synapse formation in cultured hippocampal neurons at 30-100 nM.
PF-04447943 enhances synaptic plasticity and cognitive function in rodents.

Physicochemical Properties

M.Wt	395.47
Formula	C20H25N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

References

1. Hutson PH, et al. Neuropharmacology. 2011 Sep;61(4):665-76.

2. Verhoest PR, et al. J Med Chem. 2012 Nov 8;55(21):9045-54.

3. Schwam EM, et al. Curr Alzheimer Res. 2014;11(5):413-21.

PF-04447943 (Edelinontrine, PF04447943, PF-4447943)

Biological Activity

Physicochemical Properties

References

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