PF-04449613 |CAS:1236858-52-8 Probechem Biochemicals

Chemical Structure : PF-04449613

PF-04449613 (PF-9613, PF04449613, PF 04449613)

Catalog No.: PC-35833Not For Human Use, Lab Use Only.

PF-04449613 (PF-9613, PF04449613, PF 04449613) is a potent and selective inhibitor of PDE9 with IC50 of 22 nM, >50-fold selective over PDE1C (IC50>1000 nM).

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Biological Activity

PF-04449613 (PF-9613, PF04449613, PF 04449613) is a potent and selective inhibitor of PDE9 with IC50 of 22 nM, >50-fold selective over PDE1C (IC50>1000 nM).

Physicochemical Properties

M.Wt	395.463
Formula	C21H25N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-1,5- dihydro-4H-pyrazolo [3,4-d] pyrimidin-4-one

References

1. Lai B, et al. Dev Neurobiol. 2018 Sep;78(9):859-872.
2. Michelle M Claffey, et al. J Med Chem. 2012 Nov 8;55(21):9055-68.

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PF-04449613 (PF-9613, PF04449613, PF 04449613)

Biological Activity

Physicochemical Properties

References

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