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PF-04827736

Chemical Structure : PF-04827736

CAS No.: 2230054-75-6

PF-04827736 (PF04827736;(S)-PF-04677490)

Catalog No.: PC-63527Not For Human Use, Lab Use Only.

PF-04827736 ((S)-PF-04677490) is a potent, selective PDE1 inhibitor with IC50 of 42, 9.1 and 38 nM for PDE1A, PDE1B and PDE1C, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-04827736 ((S)-PF-04677490) is a potent, selective PDE1 inhibitor with IC50 of 42, 9.1 and 38 nM for PDE1A, PDE1B and PDE1C, respectively.
    PF-04827736 displays >10-fold selectivity over PDE10A1, and >45-fold selectivity over other PDE isoforms.

    Physicochemical Properties

    M.Wt 327.388
    Formula C17H21N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-7,8-Dimethoxy-N-(1-(5-methyl-1H-pyrazol-3-yl)propan-2-yl)quinazolin-4-amine

    References

    1. Humphrey JM, et al. J Med Chem. 2018 May 10. doi: 10.1021/acs.jmedchem.8b00374.

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