PF-04827736 |CAS: 2230054-75-6 Probechem Biochemicals

Chemical Structure : PF-04827736

PF-04827736 (PF04827736;(S)-PF-04677490)

Catalog No.: PC-63527Not For Human Use, Lab Use Only.

PF-04827736 ((S)-PF-04677490) is a potent, selective PDE1 inhibitor with IC50 of 42, 9.1 and 38 nM for PDE1A, PDE1B and PDE1C, respectively.

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Biological Activity

PF-04827736 ((S)-PF-04677490) is a potent, selective PDE1 inhibitor with IC50 of 42, 9.1 and 38 nM for PDE1A, PDE1B and PDE1C, respectively.
PF-04827736 displays >10-fold selectivity over PDE10A1, and >45-fold selectivity over other PDE isoforms.

Physicochemical Properties

M.Wt	327.388
Formula	C17H21N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-7,8-Dimethoxy-N-(1-(5-methyl-1H-pyrazol-3-yl)propan-2-yl)quinazolin-4-amine

References

1. Humphrey JM, et al. J Med Chem. 2018 May 10. doi: 10.1021/acs.jmedchem.8b00374.

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PF-04827736 (PF04827736;(S)-PF-04677490)

Biological Activity

Physicochemical Properties

References

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