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PF-04856264

Chemical Structure : PF-04856264

CAS No.: 1235397-05-3

PF-04856264 (PF04856264)

Catalog No.: PC-61853Not For Human Use, Lab Use Only.

PF-04856264 is a potent, selective Nav1.7 blocker with IC50 of 28 nM, dispalys >1,000-fold selectivity over Nav1.5.

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5 mg $128 In stock
10 mg $198 In stock
25 mg $328 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-04856264 is a potent, selective Nav1.7 blocker with IC50 of 28 nM, dispalys >1,000-fold selectivity over Nav1.5.
PF-04856264 state-dependently and selectively inhibits Nav1.7 and significantly reduces OD1-induced spontaneous pain when delivered locally and systemically.

Physicochemical Properties

M.Wt 437.5
Formula C20H15N5O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-cyano-4-(2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-N-(thiazol-2-yl)benzenesulfonamide

References

1. McCormack K, et al. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):E2724-32.

2. Deuis JR, et al. Toxins (Basel). 2016 Mar 17;8(3). pii: E78.

3. Deuis JR, et al. Sci Rep. 2017 Jan 20;7:40883.

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