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PF-04995274

Chemical Structure : PF-04995274

CAS No.: 1331782-27-4

PF-04995274 (PF-4995274, TBPT)

Catalog No.: PC-61831Not For Human Use, Lab Use Only.

PF-04995274 (PF-4995274, TBPT) is a potent, selective, orally active and partial serotonin 4 receptor (5-HT4R) agonist with Ki of 0.15-0.46 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-04995274 (PF-4995274, TBPT) is a potent, selective, orally active and partial serotonin 4 receptor (5-HT4R) agonist with Ki of 0.15-0.46 nM.
PF-04995274 exhibits an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E and 0.59-0.65 nM for rat 5-HT4S/4L/4E.
PF-04995274 (3-10 mg/kg, i.v.) treatment results in prophylactic efficacy by attenuating learned fear and decreasing stress-induced depressive-like behavior in mice.
PF-04995274 is brain penetrant for investigation of cognitive disorders associated with Alzheimer's disease.

Physicochemical Properties

M.Wt 432.5214
Formula C23H32N2O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 100 mg/mL

Chemical Name/SMILES

(R)-4-((4-(((4-(Tetrahydrofuran-3-yloxy)-1,2-benzisoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol

References

1. Sawant-Basak A, et al. J Pharm Sci. 2013 Sep;102(9):3277-93.

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