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PF-05085727

Chemical Structure : PF-05085727

CAS No.: 1415637-72-7

PF-05085727 (PF 05085727;PF05085727)

Catalog No.: PC-61126Not For Human Use, Lab Use Only.

A potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11; increases brain cGMP accumulation in rodent brain regions expressing highest levels of PDE2A, demonstrates in vivo activity for clinical cognition indications.

Physicochemical Properties

M.Wt 413.408
Formula C20H18F3N7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(Azetidin-1-yl)-1-methyl-3-(1-methyl-5-(4-(trifluoromethyl)-phenyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidine

References

1. Helal CJ, et al. J Med Chem. 2017 Jul 13;60(13):5673-5698.

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