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Chemical Structure : PF-05085727
CAS No.: 1415637-72-7
Catalog No.: PC-61126Not For Human Use, Lab Use Only.
PF-05085727 is a potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PF-05085727 is a potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11.
PF-05085727 increases brain cGMP accumulation in rodent brain regions expressing highest levels of PDE2A.
PF-05085727 demonstrates in vivo activity for clinical cognition indications.
| M.Wt | 413.408 | |
| Formula | C20H18F3N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(Azetidin-1-yl)-1-methyl-3-(1-methyl-5-(4-(trifluoromethyl)-phenyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidine |
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1. Helal CJ, et al. J Med Chem. 2017 Jul 13;60(13):5673-5698.
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