Catalog No.: PC-61126Not For Human Use, Lab Use Only.
PF-05085727 is a potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11.
PF-05085727 is a potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11.
PF-05085727 increases brain cGMP accumulation in rodent brain regions expressing highest levels of PDE2A.
PF-05085727 demonstrates in vivo activity for clinical cognition indications.
