Catalog No.: PC-63166Not For Human Use, Lab Use Only.
PF-05089771 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 11 nM, >1,000-fold selectivity over Nav1.3, 1.4 and Nav1.5, 1.8.
PF-05089771 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 11 nM, >1,000-fold selectivity over Nav1.3, 1.4 and Nav1.5, 1.8.
PF-05089771 interacts with the voltage-sensor domain (VSD) of domain IV, blocks all Nav1.7 splice variants with similar potency (5N11L, 5A11S, 5A11L and 5N11S, IC50s=11=33 nM).
PF-05089771 displays high selectivity over L-type calcium channels, KvLQT and hERG potassium channels.
PF-05089771 demonstrates in vivo efficacy in a mouse capsaicin-induced neurogenic flare model.
