Chemical Structure : PF-05190457
CAS No.:
1334782-79-4
PF-05190457
(PF05190457;PF 5190457;PF5190457)
Catalog No. : PC-61098Not For Human Use, Lab Use Only.
PF-05190457 (PF-5190457) is a potent, selective, and orally bioavailable ghrelin receptor (GHSR) inverse agonist with binding pKi of 8.36.
Packing Price Stock Quantity 5 mg $98 In stock 0 1 2 3 4 5 10 mg $148 In stock 0 1 2 3 4 5 25 mg $258 In stock 0 1 2 3 4 5 50 mg $428 In stock 0 1 2 3 4 5 100 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6109801
Biological Activity
PF-05190457 (PF-5190457) is a potent, selective, and orally bioavailable ghrelin receptor (GHSR) inverse agonist with binding pKi of 8.36.
Physicochemical Properties
M.Wt
512.676
Formula
C29H32N6OS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMS) >400 mM /mL (200 mg/mL)
Ethanol: 200 mM/mL (103.2 mg/mL)
Chemical Name/SMILES
(R)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-1-(2-(5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonan-7-yl)ethan-1-one
References
1. Bhattacharya SK, et al. ACS Med Chem Lett.
2. Kong J, et al. Br J Pharmacol.
3. Denney WS, et al. Br J Clin Pharmacol.
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