Catalog No.: PC-63175Not For Human Use, Lab Use Only.
PF-05198007 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 9 nM, with no significant activity against Nav1.5 (IC50>10 uM).
PF-05198007 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 9 nM, with no significant activity against Nav1.5 (IC50>10 uM).
PF-05198007 increases action potential rheobase in small diameter mDRG neurons, demonstrates in vivo efficacy in a mouse capsaicin-induced neurogenic flare model.
