PF-05212377 |CAS:1226793-34-5 Probechem Biochemicals

Chemical Structure : PF-05212377

PF-05212377 (SAM-760;PF 5212377)

Catalog No.: PC-35004Not For Human Use, Lab Use Only.

PF-05212377 (SAM-760, PF 5212377) is a potent and selective 5-HT6 receptor antagonist with Ki of 0.32 nM (human 5HT6), shows potential therapy for the symptomatic treatment of mild to moderate Alzheimer's disease.

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Biological Activity

PF-05212377 (SAM-760, PF 5212377) is a potent and selective 5-HT6 receptor antagonist with Ki of 0.32 nM (human 5HT6), shows potential therapy for the symptomatic treatment of mild to moderate Alzheimer's disease.

Physicochemical Properties

M.Wt	356.444
Formula	C18H20N4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-methyl-1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-benzo[d]imidazole

References

1. Fullerton T, et al. Alzheimers Res Ther. 2018 Apr 5;10(1):38.

2. Fullerton T, et al. Alzheimers Res Ther. 2018 Apr 5;10(1):38.

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PF-05212377 (SAM-760;PF 5212377)

Biological Activity

Physicochemical Properties

References

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