PF-05381941 |CAS:1474022-02-0 Probechem Biochemicals

Chemical Structure : PF-05381941

CAS No.: 1474022-02-0

PF-05381941 (PF 05381941;PF05381941)

Catalog No.: PC-61199Not For Human Use, Lab Use Only.

PF-05381941 (PF 05381941, PF05381941) is a potent, dual TAK1/p38a inhibitor with IC50 of 156/186 nM respectively, with good kinome selectivity against 50 representative kinases.

Packing	Price	Stock
5 mg	$258	In stock
10 mg	$398	In stock
25 mg	$598	In stock
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Biological Activity

PF-05381941 (PF 05381941, PF05381941) is a potent, dual TAK1/p38a inhibitor with IC50 of 156/186 nM respectively, with good kinome selectivity against 50 representative kinases.
PF-05381941 inhibits LPS-stimulated release of TNF-α from human peripheral mononuclear cells with IC50 of 8 nM.

Physicochemical Properties

M.Wt	466.545
Formula	C27H26N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(tert-butyl)-1-(3-cyanophenyl)-1H-pyrazol-5-yl)-3-(3-methyl-4-(pyridin-4-yloxy)phenyl)urea

References

1. Kilty I, et al. Future Med Chem. 2015;7(1):23-33.

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PF-05381941 (PF 05381941;PF05381941)

Biological Activity

Physicochemical Properties

References

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