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PF-05381941

Chemical Structure : PF-05381941

CAS No.: 1474022-02-0

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PF-05381941 (PF 05381941;PF05381941)

Catalog No.: PC-61199Not For Human Use, Lab Use Only.

PF-05381941 (PF 05381941, PF05381941) is a potent, dual TAK1/p38a inhibitor with IC50 of 156/186 nM respectively, with good kinome selectivity against 50 representative kinases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-05381941 (PF 05381941, PF05381941) is a potent, dual TAK1/p38a inhibitor with IC50 of 156/186 nM respectively, with good kinome selectivity against 50 representative kinases.
PF-05381941 inhibits LPS-stimulated release of TNF-α from human peripheral mononuclear cells with IC50 of 8 nM.

Physicochemical Properties

M.Wt 466.545
Formula C27H26N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3-(tert-butyl)-1-(3-cyanophenyl)-1H-pyrazol-5-yl)-3-(3-methyl-4-(pyridin-4-yloxy)phenyl)urea

References

1. Kilty I, et al. Future Med Chem. 2015;7(1):23-33.

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