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Chemical Structure : PF-05387252
Catalog No.: PC-61092Not For Human Use, Lab Use Only.
A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM).
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PF-05387252 is a potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM).
PF-05387252 exhibits low nM potency in LPS- and R848-induced cytokine assays (IC50=18 nM) in human PBMCs.
PF-05387252 inhibits LPS-induced TNFα in an in vivo murine model.
| M.Wt | 429.524 | |
| Formula | C25H27N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lai CY, et al. J Immunol Res. 2017;2017:7807313.
2. Tumey LN, et al. Bioorg Med Chem Lett. 2014 May 1;24(9):2066-72.
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