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PF-05387252

Chemical Structure : PF-05387252

CAS No.: 1604034-71-0

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PF-05387252 (PF 05387252;PF05387252)

Catalog No.: PC-61092Not For Human Use, Lab Use Only.

A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-05387252 is a potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM).
    PF-05387252 exhibits low nM potency in LPS- and R848-induced cytokine assays (IC50=18 nM) in human PBMCs.
    PF-05387252 inhibits LPS-induced TNFα in an in vivo murine model.

    Physicochemical Properties

    M.Wt 429.524
    Formula C25H27N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    11H-Indolo[3,2-c]quinoline-9-carbonitrile, 2-methoxy-3-[3-(4-methyl-1-piperazinyl)propoxy]-

    References

    1. Lai CY, et al. J Immunol Res. 2017;2017:7807313.

    2. Tumey LN, et al. Bioorg Med Chem Lett. 2014 May 1;24(9):2066-72.

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