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PF-05388169

Chemical Structure : PF-05388169

CAS No.: 1604034-78-7

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PF-05388169 (PF 05388169, PF05388169)

Catalog No.: PC-61091Not For Human Use, Lab Use Only.

PF-05388169 is a potent, selective IRAK4 inhibitor with IC50 of 0.094 nM, >500-fold selectivity over IRAK1 (IC50=65 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-05388169 is a potent, selective IRAK4 inhibitor with IC50 of 0.094 nM, >500-fold selectivity over IRAK1 (IC50=65 nM).
    PF-05388169 exhibits low nM potency in LPS- and R848-induced cytokine assays (IC50=85 nM) in human PBMCs.
    PF-05388169 inhibits LPS-induced TNFα in an in vivo murine model.

    Physicochemical Properties

    M.Wt 391.427
    Formula C22H21N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    11H-Indolo[3,2-c]quinoline-9-carbonitrile, 2-methoxy-3-[2-(2-methoxyethoxy)ethoxy]-

    References

    1. Lai CY, et al. J Immunol Res. 2017;2017:7807313.

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