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Chemical Structure : PF-06273340
Catalog No.: PC-61701Not For Human Use, Lab Use Only.
PF-06273340 is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively.
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PF-06273340 (PF6273340) is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively.
PF-06273340displays selectivity over a panel of ion channels, receptors and other enzymes; exhibits in vivo efficacy in a rodent model of inflammatory pain.
| M.Wt | 479.93 | |
| Formula | C23H22ClN7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Skerratt SE, et al. J Med Chem. 2016 Nov 23;59(22):10084-10099.
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