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PF-06273340

Chemical Structure : PF-06273340

CAS No.: 1402438-74-7

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PF-06273340 (PF06273340, PF6273340)

Catalog No.: PC-61701Not For Human Use, Lab Use Only.

PF-06273340 is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-06273340 (PF6273340) is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively.
    PF-06273340displays selectivity over a panel of ion channels, receptors and other enzymes; exhibits in vivo efficacy in a rodent model of inflammatory pain.

    Physicochemical Properties

    M.Wt 479.93
    Formula C23H22ClN7O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-(2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide

    References

    1. Skerratt SE, et al. J Med Chem. 2016 Nov 23;59(22):10084-10099.

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