PF-06305591 | Nav1.8 inhibitor | Probechem Biochemicals

Chemical Structure : PF-06305591

CAS No.: 1449473-97-5

PF-06305591 (PF06305591;PF 06305591)

Catalog No.: PC-35885Not For Human Use, Lab Use Only.

PF-06305591 (PF06305591) is a potent, highly selective selective NaV1.8 blocker with IC50 of 15 nM, displays no significant activity against other sodium channel subtypes, K+ channels and Ca2+ channels.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$258	In stock
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Biological Activity

PF-06305591 (PF06305591) is a potent, highly selective selective NaV1.8 blocker with IC50 of 15 nM, displays no significant activity against other sodium channel subtypes, K+ channels and Ca2+ channels.
PF-06305591 displays excellent preclinical in vitro ADME and safety profile.

Physicochemical Properties

M.Wt	274.368
Formula	C15H22N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S)-3-amino-3-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)-2-methylpropanamide

References

1. Brown AD, et al. Bioorg Med Chem. 2019 Jan 1;27(1):230-239.

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PF-06305591 (PF06305591;PF 06305591)

Biological Activity

Physicochemical Properties

References

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