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PF-06426779

Chemical Structure : PF-06426779

CAS No.: 1817628-40-2

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PF-06426779 (PF06426779)

Catalog No.: PC-35553Not For Human Use, Lab Use Only.

PF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM.
    PF-06426779 displays excellent selectivity against the human kinome, and >100-fold selectivity for IRAK4 over IRAK1.

    Physicochemical Properties

    M.Wt 347.346
    Formula C17H18FN3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(((2S,3S,4S)-4-Fluoro-3-methyl-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide

    References

    1. De Nardo D, et al. J Biol Chem. 2018 Aug 3. pii: jbc.RA118.003314.

    2. Lee KL, et al. J Med Chem. 2017 Jul 13;60(13):5521-5542.

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