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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Sodium-coupled Citrate Transporter (NaCT,SLC13A5)-PF-06649298
PF-06649298

Chemical Structure : PF-06649298

CAS No.: 1854061-16-7

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PF-06649298 (PF 06649298, PF06649298)

Catalog No.: PC-60604Not For Human Use, Lab Use Only.

PF-06649298 (PF06649298) is a potent, selective inhibitor of the Na+/citrate transporter NaCT (SLC13A5) that shows inhibition of citrate uptake in the HEKNaCT cells with IC50 of 0.41 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-06649298 (PF06649298) potent, selective inhibitor of the Na+/citrate transporter NaCT (SLC13A5) that shows inhibition of citrate uptake in the HEKNaCT cells with IC50 of 0.41 uM.
PF-06649298 displays >60-fold selectvity over NaDC1 and NaDC3.

Physicochemical Properties

M.Wt 294.347
Formula C16H22O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-(4-(tert-butyl)phenethyl)-2-hydroxysuccinic acid

References

1. Pajor AM, et al. Mol Pharmacol. 2016 Dec;90(6):755-765.

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