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PF-06650833

Chemical Structure : PF-06650833

CAS No.: 1817626-54-2

PF-06650833 (PF06650833;Zimlovisertib)

Catalog No.: PC-45740Not For Human Use, Lab Use Only.

PF-06650833 (PF06650833) is a potent and selective IRAK4 inhibitor with IC50 of 0.2 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Zimlovisertib (PF-06650833) is a potent and selective IRAK4 inhibitor with IC50 of 0.2 nM.
Zimlovisertib (PF-06650833) has IC50 of 2 nM in the PBMC assay as well as in a human whole blood assay.
Zimlovisertib (PF-06650833) shows excellent kinase selectivity in a panel of 278 kinases.
Zimlovisertib (PF-06650833) significantly inhibits LPS-induced TNFα in a dose dependent manner in rats model (0.3-30 mg/kg).
Zimlovisertib (PF-06650833) has favorable in vitro and in vivo ADME profiles and orally active.

Physicochemical Properties

M.Wt 361.3675
Formula C18H20FN3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 33 mg/mL

Chemical Name/SMILES

6-Isoquinolinecarboxamide, 1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-

References

1. Lee KL, et al. J Med Chem. 2017 Jul 13;60(13):5521-5542.

2. Seganish WM. Expert Opin Ther Pat. 2016 Aug;26(8):917-32.

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