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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Sodium-coupled Citrate Transporter (NaCT,SLC13A5)-PF-06678419
PF-06678419

Chemical Structure : PF-06678419

CAS No.: 2055468-48-7

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PF-06678419 (PF 06678419, PF06678419)

Catalog No.: PC-60603Not For Human Use, Lab Use Only.

PF-06678419 (PF06678419) is a potent, selective inhibitor of the Na+/citrate transporter NaCT (SLC13A5) that shows inhibition of citrate uptake in the HEKNaCT cells with IC50 of 0.44 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-06678419 (PF06678419) is a potent, selective inhibitor of the Na+/citrate transporter NaCT (SLC13A5) that shows inhibition of citrate uptake in the HEKNaCT cells with IC50 of 0.44 uM.
    PF-06678419 displays relatively selectivity over NaDC1 and NaDC3 (7-10-fold).

    Physicochemical Properties

    M.Wt 364.135
    Formula C12H13IO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-2-hydroxy-2-(4-iodophenethyl)succinic acid

    References

    1. Pajor AM, et al. Mol Pharmacol. 2016 Dec;90(6):755-765.

    2. Huard K, et al. Sci Rep. 2015 Dec 1;5:17391.

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