Catalog No.: PC-60295Not For Human Use, Lab Use Only.
Mavelertinib (PF-06747775) is a potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.
Mavelertinib (PF-06747775) is a potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.
PF-06747775 displays excellent selectivity over wild-type EGFR (IC50=307 nM), and desirable ADME properties.
PF-06747775 shows potential for treatment of EGFR T790M mutation in advanced NSCLC.
