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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Sodium-coupled Citrate Transporter (NaCT,SLC13A5)-PF-06761281
PF-06761281

Chemical Structure : PF-06761281

CAS No.: 1854061-19-0

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PF-06761281 (PF 06761281, PF06761281)

Catalog No.: PC-61147Not For Human Use, Lab Use Only.

PF-06761281 is a potent, selective sodium-coupled citrate transporter (NaCT or SLC13A5) with IC50 of 0.51 uM, >20-fold selectivity over NaDC1 and NaDC3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-06761281 is a potent, selective sodium-coupled citrate transporter (NaCT or SLC13A5) with IC50 of 0.51 uM, >20-fold selectivity over NaDC1 and NaDC3.
    PF-06761281 demonstrates dose-dependent inhibition of radioactive [(14)C]citrate uptake in liver and kidney in vivo.
    PF-06761281 reduces fasting plasma glucose concentrations with suitable in vivo pharmacokinetic profile.

    Physicochemical Properties

    M.Wt 283.28
    Formula C13H17NO6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-2-Hydroxy-2-(2-(2-methoxy-5-methylpyridin-3-yl)ethyl)-succinic Acid

    References

    1. Huard K, et al. J Med Chem. 2016 Feb 11;59(3):1165-75.

    2. Rives ML, et al. Mol Pharmacol. 2016 Dec;90(6):766-774.

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