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Chemical Structure : PF-06764427
Catalog No.: PC-35477Not For Human Use, Lab Use Only.
PF-06764427 (PF06764427) is a potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 55 nM, has no measurable agonist or PAM activity at the M2-M5 receptors at 10 uM.
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PF-06764427 (PF06764427) is a potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 55 nM, has no measurable agonist or PAM activity at the M2-M5 receptors at 10 uM.
PF-06764427 induces a 212-fold shift in the ACh CRC at 10 uM in the PathHunter Arrβ2 assay.
PF-06764427 demonstrates robust potentiation of acetylcholine across the G-protein and Arrβ2 pathways, adequate brain availability, favorable pharmacokinetic properties and invivo efficacy in a mouse amphetamine-stimulated LMA model.
| M.Wt | 431.496 | |
| Formula | C24H25N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Moran SP, et al. Neuropsychopharmacology. 2018 Jul;43(8):1763-1771.
2. Rook JM, et al. ACS Chem Neurosci. 2018 May 8. doi: 10.1021/acschemneuro.8b00131.
3. Davoren JE, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):650-655.
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