Catalog No.: PC-35477Not For Human Use, Lab Use Only.
PF-06764427 (PF06764427) is a potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 55 nM, has no measurable agonist or PAM activity at the M2-M5 receptors at 10 uM.
PF-06764427 (PF06764427) is a potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 55 nM, has no measurable agonist or PAM activity at the M2-M5 receptors at 10 uM.
PF-06764427 induces a 212-fold shift in the ACh CRC at 10 uM in the PathHunter Arrβ2 assay.
PF-06764427 demonstrates robust potentiation of acetylcholine across the G-protein and Arrβ2 pathways, adequate brain availability, favorable pharmacokinetic properties and invivo efficacy in a mouse amphetamine-stimulated LMA model.
