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Chemical Structure : PF-06795071
Catalog No.: PC-63525Not For Human Use, Lab Use Only.
PF-06795071 is a potent, selective, covalent Monoacylglycerol Lipase (MAGL) inhibitor with IC50 of 3 nM, >1,000-fold selectivity over FAAH.
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PF-06795071 is a potent, selective, covalent Monoacylglycerol Lipase (MAGL) inhibitor with IC50 of 3 nM, >1,000-fold selectivity over FAAH.
2075629-81-9 shows significant solubility improvements as compared with analogs with a similar profile, also exhibits excellent serine hydrolase selectivity and a clean in vitro safety profile.
2075629-81-9 shows good CNS exposure in mouse and a suitable PK profile for use as a tool to explore in vivo efficacy.
| M.Wt | 399.346 | |
| Formula | C18H17F4N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. McAllister La, et al. J Med Chem. 2018 Apr 12;61(7):3008-3026.
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