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PF-06807656

Chemical Structure : PF-06807656

CAS No.: 2213468-04-1

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PF-06807656 (PF06807656)

Catalog No.: PC-63348Not For Human Use, Lab Use Only.

PF-06807656 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1a) inhibitor with IC50 of 61 nM for hROMK in patch-clamp assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-06807656 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1a) inhibitor with IC50 of 61 nM for hROMK in patch-clamp assays.
    PF-06807656 is highly selective for inhibition of human over rat ROMK and to be insensitive to the N171D pore mutation.

    Physicochemical Properties

    M.Wt 449.91
    Formula C19H20ClN5O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(N-(4-chlorophenyl)sulfamoyl)-4-methoxy-N-(1-(2-methyl-2H-1,2,3-triazol-4-yl)ethyl)benzamide

    References

    1. Sammons MF, et al. ACS Med Chem Lett. 2018 Jan 19;9(2):125-130.

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