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PF-06815189

Chemical Structure : PF-06815189

CAS No.: 2218484-75-2

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PF-06815189 (PF06815189)

Catalog No.: PC-62528Not For Human Use, Lab Use Only.

PF-06815189 is a potent, selective phosphodiesterase 2 (PDE2) inhibitor with IC50 of 0.4 nM, >1,000-fold selectivity over PDE5.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-06815189 is a potent, selective phosphodiesterase 2 (PDE2) inhibitor with IC50 of 0.4 nM, >1,000-fold selectivity over PDE5.
    PF-06815189 also demonstrates no significant activities (EC50 >10 μM) in a broad spectrum BioPrint panel.
    PF-06815189 possesses favorable pharmacological and in vitro ADME profile, the pharmacokinetic attributes.

    Physicochemical Properties

    M.Wt 418.38
    Formula C19H17F3N6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-(1,3-dimethyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)-5-(hydroxymethyl)-2-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

    References

    1. Stepan AF, et al. ACS Med Chem Lett. 2018 Jan 4;9(2):68-72.

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