PF-06815345 |CAS:1900686-46-5 Probechem Biochemicals

Chemical Structure : PF-06815345

PF-06815345 (PF 6815345)

Catalog No.: PC-63169Not For Human Use, Lab Use Only.

PF-06815345 (PF 6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay.

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Biological Activity

PF-06815345 (PF 6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay.
PF-06815345 is identified after optimization of the prodrug moiety to maximize intestinal stability achieving liver targeting of the active compound after prodrug turnover by carboxylesterase (CES1).

Physicochemical Properties

M.Wt	598.036
Formula	C27H29ClFN9O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(5-(4-(4-((3-chloropyridin-2-yl)((R)-piperidin-3-yl)carbamoyl)-2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)-1H-tetrazol-1-yl)ethyl ethyl carbonate

References

1. McClure KF, et al. Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16218-16222.

2. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3.

PF-06815345 (PF 6815345)

Biological Activity

Physicochemical Properties

References

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