PF-06815345 hydrochloride

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Chemical Structure : PF-06815345 hydrochloride

Catalog No.: PC-26863Not For Human Use, Lab Use Only.

PF-06815345 hydrochloride (PF-6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PF-06815345 hydrochloride (PF-6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay.
PF-06815345 is identified after optimization of the prodrug moiety to maximize intestinal stability achieving liver targeting of the active compound after prodrug turnover by carboxylesterase (CES1).

Physicochemical Properties

M.Wt	634.49
Formula	C27H30Cl2FN9O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(5-(4-(4-((3-chloropyridin-2-yl)((R)-piperidin-3-yl)carbamoyl)-2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)-1H-tetrazol-1-yl)ethyl ethyl carbonate hydrochloride

References

1. McClure KF, et al. Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16218-16222.

2. Daniel Pettersen, et al. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3.

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