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Chemical Structure : PF-06827443
Catalog No.: PC-35482Not For Human Use, Lab Use Only.
PF-06827443 (PF06827443) is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC50 of 47 nM, shows no activity against M2-M5 at 10 uM.
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PF-06827443 (PF06827443) is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC50 of 47 nM, shows no activity against M2-M5 at 10 uM.
PF-06827443 induces cholinergic adverse events and convulsion at therapeutic indices similar to previous compounds with more agonist activity.
| M.Wt | 404.466 | |
| Formula | C24H24N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Davoren JE, et al. J Med Chem. 2017 Aug 10;60(15):6649-6663.
2. Moran SP, et al. ACS Chem Neurosci. 2018 Apr 25. doi: 10.1021/acschemneuro.8b00106.
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