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PF-06827443

Chemical Structure : PF-06827443

CAS No.: 2115022-67-6

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PF-06827443 (PF06827443)

Catalog No.: PC-35482Not For Human Use, Lab Use Only.

PF-06827443 (PF06827443) is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC50 of 47 nM, shows no activity against M2-M5 at 10 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-06827443 (PF06827443) is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC50 of 47 nM, shows no activity against M2-M5 at 10 uM.
    PF-06827443 induces cholinergic adverse events and convulsion at therapeutic indices similar to previous compounds with more agonist activity.

    Physicochemical Properties

    M.Wt 404.466
    Formula C24H24N2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((3R,4S)-3-Hydroxytetrahydro-pyran-4-yl)-5-methyl-6-(4-oxazol-4-yl-benzyl)-2,3-dihydro-isoindol-1-one

    References

    1. Davoren JE, et al. J Med Chem. 2017 Aug 10;60(15):6649-6663.

    2. Moran SP, et al. ACS Chem Neurosci. 2018 Apr 25. doi: 10.1021/acschemneuro.8b00106.

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