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PF-07038124

Chemical Structure : PF-07038124

CAS No.: 2415085-44-6

PF-07038124 (PF 07038124)

Catalog No.: PC-20682Not For Human Use, Lab Use Only.

PF-07038124 (PF 07038124) is a highly potent, selective PDE4 inhibitor with IC50 of 0.5 nM for PDE4B2 in SPA assays, inhibits cytokines release of IL-4, IL-13 and IFNy from human PBMCs stimulated with PHA-L with IC50 of 135, 4.1, and 1.06 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PF-07038124 (PF 07038124) is a highly potent, selective PDE4 inhibitor with IC50 of 0.5 nM for PDE4B2 in SPA assays, inhibits cytokines release of IL-4, IL-13 and IFNy from human PBMCs stimulated with PHA-L with IC50 of 135, 4.1, and 1.06 nM, respectively.

Physicochemical Properties

M.Wt 327.19
Formula C18H22BNO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

CCCOC1=C(OC)C=CC(C2=CN=CC([C@@]3([H])CB(OC3)O)=C2)=C1

References

1. Patent WO2020070651A1 (Example 4).

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